RIPPLE

**RIPPLE COMMENT** According to Financial Post (established source, credibility tier: 90/100), a recent study published in the New England Journal of Medicine found that AJOVY significantly reduced monthly migraine and headache days in children and adolescents with episodic migraine compared to placebo over a 12-week period. This breakthrough treatment has been deemed safe and effective for both pediatric and adult patients. **CAUSAL CHAIN** The direct cause → effect relationship is as follows: The study's findings on AJOVY's efficacy and safety profile will likely influence healthcare providers' prescribing habits, leading to increased adoption of this treatment option. This, in turn, may lead to improved patient outcomes, including reduced migraine and headache days, which can have a significant impact on patients' quality of life. Intermediate steps include: * Increased awareness among healthcare professionals about AJOVY's benefits and safety profile * Changes in clinical practice guidelines or recommendations from professional organizations * Potential inclusion of AJOVY in national treatment protocols for pediatric migraine The timing of these effects is likely to be short-term, with increased adoption of the treatment option expected within the next 6-12 months. **DOMAINS AFFECTED** * National Health > National Health Standards > Patient Safety Standards * Healthcare Policy and Practice * Medical Research and Development * Public Health Education **EVIDENCE TYPE** * Research study (published in a reputable medical journal) **UNCERTAINTY** While the study's findings are promising, there may be uncertainty surrounding the long-term effects of AJOVY on pediatric patients. Additionally, factors such as insurance coverage and accessibility of the treatment option may influence its adoption rate. --- Source: [Financial Post](https://financialpost.com/globe-newswire/ajovy-fremanezumab-vfrm-significantly-reduced-monthly-migraine-and-headache-days-in-children-and-adolescents-with-episodic-migraine-compared-to-placebo-in-the-space-trial-results-published-in) (established source, credibility: 90/100)

Here is the RIPPLE comment: According to Financial Post (established source), a recent article reports that the Technical Standards and Safety Authority (TSSA) has urged Ontarians to keep gas meters and fuel-burning appliance vents free from snow and ice during the ongoing winter storm. This warning aims to prevent potential hazards, such as carbon monoxide poisoning, which can occur when snow or ice blocks ventilation outlets. The causal chain of effects begins with the immediate risk of carbon monoxide poisoning due to blocked ventilation outlets (direct cause). If ventilation outlets are obstructed, carbon monoxide can accumulate inside homes, potentially leading to severe health consequences. In the short term, this could result in increased emergency room visits and hospitalizations for carbon monoxide poisoning cases. In the long term, if the issue persists without adequate measures being taken, it may lead to changes in national health standards regarding ventilation requirements for fuel-burning appliances. This could involve updates to building codes or safety regulations to ensure that homes are designed with proper ventilation systems to prevent such hazards. The domains affected by this news event include National Health (specifically patient safety standards) and potentially Environment (if the issue of carbon monoxide poisoning leads to changes in policy regarding fuel-burning appliances). The evidence type is an official announcement from a regulatory agency, the TSSA. There are uncertainties surrounding the long-term effects, as it depends on how effectively governments and regulatory agencies respond to this issue. If... then, the lack of action could lead to further health consequences and changes in policy, while prompt and effective measures might mitigate these risks.